中轴型脊柱关节炎对患者

休闲体育活动水平的长期影响：

一项随机对照试验的二次分析

探讨为期3个月的锻炼计划对中轴型脊柱关节炎（axSpA）个体休闲时段体育活动水平的长期影响。

对来自随机对照试验中的名axSpA个体的数据进行了二次分析。运动组（EG）参加了为期3个月的锻炼计划，对照组（CG）未接受干预。休闲时段体育活动通过问卷进行测量（体育活动：中等/剧烈身体活动≥1小时/周）。通过强直性脊柱炎疾病活动量表（ASDAS；评分高=越差）来测量疾病活动。使用卡方检验，逻辑回归和混合模型在意向性治疗的基础上进行了统计分析。

在为期12个月的随访中，EG的体育活动个体明显多于CG[29（67％）对比13（30％），p0.]，每周运动2-3次[25（58％）对比15（34％），p=0.02]，户外光照下的运动较少[3（8％）对比14（44％），p=0.]。“参与EG”（OR6.7，95％CI2.4-18.6，p0.）和“基线活跃”（OR4.7，95％CI1.4-15.8，p=0.01）是与体育活动最相关的因素。ASDAS对照组之间没有差异（p=0.79）。

为期3个月的锻炼计划对axSpA患者的休闲时段体育活动具有长期有益影响，因此表明其对健康状况更为有益。仍然很少有人继续进行强化治疗，12个月后两组之间的疾病活动没有差异。

Objective

Toexplorethelongtermeffectofa3-monthexerciseprogramonleisuretimephysicalactivitylevelinindividualswithaxialspondyloarthritis(axSpA).

Methods

AsecondaryanalysiswasperformedondatafromindividualswithaxSpAwhowereincludedinarandomizedcontrolledtrial.Theexercisegroup(EG)participatedina3-monthexerciseprogramwhilethecontrolgroup(CG)receivednointervention.Physicalactivityduringleisuretimewasmeasuredwithaquestionnaire(physicallyactive:≥1h/weekwithmoderate/vigorousintensityphysicalactivity).DiseaseactivitywasmeasuredwiththeAnkylosingSpondylitisDiseaseActivityScale(ASDAS;higherscore=worst).Statisticalanalyseswereperformedonanintention-to-treatbasisusingchi-squaretests,logisticregression,andmixedmodels.

Results

Atthe12-monthfollowup,significantlymoreindividualsintheEGthanintheCGwerephysicallyactive[29(67%)vs13(30%),p0.]andexercised2–3times/week[25(58%)vs15(34%),p=0.02],andfewerexercisedatlightintensity[3(8%)vs14(44%),p=0.].“ParticipationintheEG”(OR6.7,95%CI2.4–18.6,p0.)and“beingphysicallyactiveatbaseline”(OR4.7,95%CI1.4–15.8,p=0.01)werethefactorsmostassociatedwithbeingphysicallyactive.TherewerenodifferencesbetweenthegroupsinASDAS(p=0.79).

Conclusion

A3-monthexerciseprogramhadabeneficiallongtermeffectonleisuretimephysicalactivityinindividualswithaxSpA,thusindicatingamorebeneficialhealthprofile.Still,fewindividualscontinuedtheintensiveprogram,andtherewasnodifferencebetweenthegroupsindiseaseactivityafter12months.

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